Practical synthesis of Abbott amino-diol: A core unit of the potent renin inhibitor Zankiren

被引：20

作者：

Chandrasekhar, S ^{[1
]}

Mohapatra, S ^{[1
]}

Yadav, JS ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON | 1999年 / 55卷 / 15期

关键词：

D O I：

10.1016/S0040-4020(99)00148-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Abbott amino-diol (2S,3R, 4S)-2-amino-1-cyclohexyl-6-methyl heptane-3,4-diol 1, a main structural constituent of the orally active renin inhibitor Zankiren has been synthesized using Sharpless asymmetric aminohydroxylation as the key step. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4763 / 4768

页数：6

共 23 条

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