Before It Gets Started: Regulating Translation at the 5′ UTR

被引：189

作者：

Araujo, Patricia R. ^{[1
]}

Yoon, Kihoon ^{[1
,2
]}

Ko, Daijin ^{[3
]}

Smith, Andrew D. ^{[4
]}

Qiao, Mei ^{[1
]}

Suresh, Uthra ^{[1
]}

Burns, Suzanne C. ^{[1
]}

Penalva, Luiz O. F. ^{[1
,5
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Greehey Childrens Canc Res Inst, San Antonio, TX 78229 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA

[3] Univ Texas San Antonio, Dept Management Sci & Stat, San Antonio, TX 78249 USA

[4] Univ So Calif, Dept Biol Sci, Los Angeles, CA 90089 USA

[5] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA

来源：

COMPARATIVE AND FUNCTIONAL GENOMICS | 2012年

关键词：

OPEN READING FRAMES; FACTOR-BETA-3; MESSENGER-RNA; IRON-RESPONSIVE ELEMENT; POSTTRANSCRIPTIONAL REGULATION; EUKARYOTIC TRANSLATION; DROSOPHILA UNR; GENE; INITIATION; MECHANISM; MUTATIONS;

D O I：

10.1155/2012/475731

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Translation regulation plays important roles in both normal physiological conditions and diseases states. This regulation requires cis-regulatory elements located mostly in 5' and 3' UTRs and trans-regulatory factors (e. g., RNA binding proteins (RBPs)) which recognize specific RNA features and interact with the translation machinery to modulate its activity. In this paper, we discuss important aspects of 5' UTR-mediated regulation by providing an overview of the characteristics and the function of the main elements present in this region, like uORF (upstream open reading frame), secondary structures, and RBPs binding motifs and different mechanisms of translation regulation and the impact they have on gene expression and human health when deregulated.

引用

页数：8

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