Clinical impact of mild carbohydrate intolerance in pregnancy: A study of 2904 nondiabetic Danish women with risk factors for gestational diabetes mellitus

被引:113
作者
Jensen, DM
Damm, P
Sorensen, B
Molsted-Pedersen, L
Westergaard, JG
Klebe, J
Beck-Nielsen, H
机构
[1] Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense, Denmark
[2] Univ Copenhagen, Rigshosp, Dept Gynecol & Obstet, DK-2100 Copenhagen, Denmark
[3] Odense Univ, Dept Gynecol & Obstet, DK-5230 Odense M, Denmark
[4] Univ Copenhagen, Copenhagen Cty Hosp, Dept Gynecol & Obstet, Copenhagen, Denmark
[5] Aarhus Univ Hosp, Dept Gynecol & Obstet, DK-8000 Aarhus, Denmark
关键词
carbohydrate intolerance; gestational diabetes mellitus; maternal-fetal outcome; oral glucose tolerance test; pregnancy; shoulder dystocia;
D O I
10.1067/mob.2001.115864
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: The objective was to study the clinical impact of mild carbohydrate intolerance In pregnant women with risk factors for gestational diabetes mellitus. STUDY DESIGN: This was a historical cohort study of 2904 pregnant women examined for gestational diabetes on the basis of risk factors. Information on oral glucose tolerance test results and clinical outcomes was collected from laboratory charts and medical records. RESULTS: The following outcomes Increased significantly with increasing glucose values during the oral glucose tolerance test: shoulder dystocia, macrosomia, emergency cesarean section, assisted delivery, hypertension, and Induction of labor. However, when corrections were made for other risk factors, hypertension and induction of labor were only marginally associated with glucose levels. CONCLUSION: In a group of nondiabetic pregnant women with risk factors for gestational diabetes, there was a graded increase in the frequency of shoulder dystocia and other maternal-fetal complications with Increasing glucose levels during an oral glucose tolerance test.
引用
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页码:413 / 419
页数:7
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