Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer

被引：46

作者：

Giuriato, S ^{[1
]}

Rabin, K ^{[1
]}

Fan, AC ^{[1
]}

Shachaf, CM ^{[1
]}

Felsher, DW ^{[1
]}

机构：

[1] Stanford Univ, Div Oncol, Stanford, CA 94305 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2004年 / 14卷 / 01期

关键词：

transgenic mice; tetracycline regulatory system; tamoxifen system; mouse knockouts; oncogenes; MYC;

D O I：

10.1016/j.semcancer.2003.11.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ability to model cancer in the mouse has provided a robust methodology to dissect the molecular etiology of cancer. These models serve as potentially powerful platforms to preclinically evaluate novel therapeutics. In particular, the recent development of strategies to conditionally induce the or knockout the function of genes in a tissue specific manner has enabled investigators to engineer mice to demonstrate that the targeted inactivation of specific oncogenes can be effective in inducing sustained regression of tumors. Thus, these animal models will be useful to define the specific genes that will be therapeutically useful to target for the treatment of particular human cancers. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：3 / 11

页数：9

相关论文

共 59 条

[1] Mdx mice inducibly expressing dystrophin provide insights into the potential of gene therapy for Duchenne muscular dystrophy [J].

Ahmad, A ;

Brinson, M ;

Hodges, BL ;

Chamberlain, JS ;

Amalfitano, A .

HUMAN MOLECULAR GENETICS, 2000, 9 (17) :2507-2515

[2]

Andreú T, 2001, CANCER RES, V61, P6925

[3] Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse [J].

Buchholz, F ;

Refaeli, Y ;

Trumpp, A ;

Bishop, JM .

EMBO REPORTS, 2000, 1 (02) :133-139

[4] Essential role for oncogenic Ras in tumour maintenance [J].

Chin, L ;

Tam, A ;

Pomerantz, J ;

Wong, M ;

Holash, J ;

Bardeesy, N ;

Shen, Q ;

O'Hagan, R ;

Pantginis, J ;

Zhou, H ;

Horner, JW ;

Cordon-Cardo, C ;

Yancopoulos, GD ;

DePinho, RA .

NATURE, 1999, 400 (6743) :468-472

[5] Flipping the oncogene switch - illumination of tumor maintenance and regression [J].

Chin, L ;

DePinho, RA .

TRENDS IN GENETICS, 2000, 16 (04) :147-150

[6] Advances in vivo bioluminescence imaging of gene expression [J].

Contag, CH ;

Bachmann, MH .

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2002, 4 :235-260

[7] c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations [J].

D'Cruz, CM ;

Gunther, EJ ;

Boxer, RB ;

Hartman, JL ;

Sintasath, L ;

Moody, SE ;

Cox, JD ;

Ha, SI ;

Belka, GK ;

Golant, A ;

Cardiff, RD ;

Chodosh, LA .

NATURE MEDICINE, 2001, 7 (02) :235-239

[8] Advancing animal models of neoplasia through in vivo bioluminescence imaging [J].

Edinger, M ;

Cao, YA ;

Hornig, YS ;

Jenkins, DE ;

Verneris, MR ;

Bachmann, MH ;

Negrin, RS ;

Contag, CH .

EUROPEAN JOURNAL OF CANCER, 2002, 38 (16) :2128-2136

[9] Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen [J].

Ewald, D ;

Li, MG ;

Efrat, S ;

Auer, G ;

Wall, RJ ;

Furth, PA ;

Hennighausen, L .

SCIENCE, 1996, 273 (5280) :1384-1386

[10] Cancer revoked: oncogenes as therapeutic targets [J].

Felsher, DW .

NATURE REVIEWS CANCER, 2003, 3 (05) :375-380

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