Design and synthesis of novel [60]fullerene derivatives as potential HIV aspartic protease inhibitors

被引：107

作者：

Marcorin, GL

Da Ros, T

Castellano, S

Stefancich, G

Bonin, I

Miertus, S

Prato, M

机构：

[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[2] Int Ctr Sci & High Technol, ICS UNIDO, I-34012 Trieste, Italy

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 25期

关键词：

D O I：

10.1021/ol000217y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two water-soluble fullerene derivatives have been computer designed and synthesized. They may exhibit interesting anti-HIV activity owing to the presence of two ammonium groups strategically located on the spheroid surface.

引用

页码：3955 / 3958

页数：4

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