An antiinflammatory galactolipid from rose hip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro

被引：154

作者：

Larsen, E

Kharazmi, A

Christensen, LP

Christensen, SB

机构：

[1] Res Ctr Aarslev, Danish Inst Agr Sci, Dept Food Sci, DK-5792 Aarslev, Denmark

[2] Copenhagen Univ Hosp, Rigshosp, Dept Clin Microbiol, DK-2200 Copenhagen, Denmark

[3] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen, Denmark

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 07期

关键词：

D O I：

10.1021/np0300636

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The galactolipid (2S)-1,2-di-O-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyl]-3-O-beta-D-galactopyranosyl glycerol (1) isolated from dried and milled fruits of Rosa caning by bioassay-guided fractionation is an antiinflammatory agent with inhibitory effects on chemotaxis of human peripheral blood neutrophils in vitro. The inhibition of cell migration is not related to toxicity. The presence of 1 in rose hips may explain the clinically observed antiinflammatory properties of rose hip herbal remedies.

引用

收藏

页码：994 / 995

页数：2

相关论文

共 20 条

[1] A MONOACYL GALACTOSYLGLYCEROL FROM SONCHUS-ARVENSIS [J].

BARUAH, P ;

BARUAH, NC ;

SHARMA, RP ;

BARUAH, JN ;

KULANTHAIVEL, P ;

HERZ, W .

PHYTOCHEMISTRY, 1983, 22 (08) :1741-1744

[2]

HARRIS ED, 1988, INFLAMMATION BASIC P, P751

[3] MILLERENOLIDES, SESQUITERPENE LACTONES FROM MILLERIA-QUINQUEFLORA [J].

JAKUPOVIC, J ;

CASTRO, V ;

BOHLMANN, F .

PHYTOCHEMISTRY, 1987, 26 (07) :2011-2017

[4] COMPUTER-ASSISTED IMAGE-ANALYSIS ASSAY OF HUMAN NEUTROPHIL CHEMOTAXIS INVITRO [J].

JENSEN, P ;

KHARAZMI, A .

JOURNAL OF IMMUNOLOGICAL METHODS, 1991, 144 (01) :43-48

[5] Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo [J].

Kharazmi A. ;

Winther K. .

InflammoPharmacology, 1999, 7 (4) :377-386

[6] SAPONIN AND SAPOGENOL .46. ON THE CONSTITUENTS IN AERIAL PART OF AMERICAN ALFALFA, MEDICAGO-SATIVA L - THE STRUCTURE OF DEHYDROSOYASAPONIN-I [J].

KITAGAWA, I ;

TANIYAMA, T ;

MURAKAMI, T ;

YOSHIHARA, M ;

YOSHIKAWA, M .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1988, 108 (06) :547-554

[7] GLYCEROGLYCOLIPIDS FROM CITRUS HYSTRIX, A TRADITIONAL HERB IN THAILAND, POTENTLY INHIBIT THE TUMOR-PROMOTING ACTIVITY OF 12-O-TETRADECANOYLPHORBOL 13-ACETATE IN MOUSE SKIN [J].

MURAKAMI, A ;

NAKAMURA, Y ;

KOSHIMIZU, K ;

OHIGASHI, H .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1995, 43 (10) :2779-2783

[8]

MURAKAMI N, 1991, CHEM PHARM BULL, V39, P2277

[9]

OHTA N, 1991, CHEM PHARM BULL, V39, P1337

[10] Prieurianoside, a protolimonoid glucoside from the leaves of Trichilia prieuriana [J].

Olugbade, TA ;

Adesanya, SA .

PHYTOCHEMISTRY, 2000, 54 (08) :867-870