Nonoxynol-9 enhances rectal infection by herpes simplex virus in mice

被引：41

作者：

Phillips, DM ^{[1
]}

Zacharopoulos, VR ^{[1
]}

机构：

[1] Populat Council, New York, NY 10021 USA

来源：

CONTRACEPTION | 1998年 / 57卷 / 05期

关键词：

nonoxynol-9; herpes simplex virus; rectal mucosa; microbicide; herpesviruses; mouse;

D O I：

10.1016/S0010-7824(98)00040-7

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Pretreating the rectum of mice with nonoxynol-9 (N9) or spermicides containing N9 before infecting via the rectal route with herpes simplex virus 2 (HSV-2) increased the likelihood of infection and shortened the time until infection. Microscopic analysis indicated that N9 rapidly caused exfoliation of the rectal epithelium, exposing the underlying connective tissue. These findings suggest that use of N9-containing products during rectal intercourse may increase the risk of infection with HSV-2 or other sexually transmitted pathogens. CONTRACEPTION 1998;57: 341-348 (C) 1998 Elsevier Science Inc. All rights reserved.

引用

页码：341 / 348

页数：8

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