Evaluation of once-weekly therapy for tuberculosis using isoniazid plus rifamycins in the mouse aerosol infection model

被引：23

作者：

Brooks, JV ^{[1
]}

Orme, IM ^{[1
]}

机构：

[1] Colorado State Univ, Dept Microbiol, Mycobacteria Res Labs, Ft Collins, CO 80523 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 11期

关键词：

D O I：

10.1128/AAC.42.11.3047

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Once-weekly therapy with combinations of isoniazid plus a rifamycin was tested in the mouse low-dose aerosol infection model against two strains of Mycobacterium tuberculosis. Combinations of isoniazid and rifalizil and isoniazid and rifapentine were both highly effective. These animal model data thus support the evaluation of these regimens under clinical conditions.

引用

页码：3047 / 3048

页数：2

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