Structural diversity of streptokinase and activation of human plasminogen

被引：13

作者：

Lizano, S ^{[1
]}

Johnston, KH

机构：

[1] New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Dept Microbiol Immunol & Parasitol, New Orleans, LA 70112 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 07期

关键词：

D O I：

10.1128/IAI.73.7.4451-4453.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The beta domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative function for this molecular motif in streptococcal disease.

引用

页码：4451 / 4453

页数：3

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