Characterization of an ocular photopigment capable of driving pupillary constriction in mice

被引:482
作者
Lucas, RJ
Douglas, RH
Foster, RG
机构
[1] Charing Cross Hosp, Imperial Coll, Sch Med,Dept Integrat & Mol Neurosci, Div Neurosci & Psychol Med, London W6 8RF, England
[2] City Univ London, Dept Optometry & Visual Sci, Appl Vis Res Ctr, London EC1V 0HB, England
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1038/88443
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This work demonstrates that transgenic mice lacking both rod and cone photoreceptors (rd/rd cl) retain a pupillary light reflex (PLR) that does not rely on local iris photoreceptors. These data, combined with previous reports that rodless and coneless mice show circadian and pineal responses to light, suggest that multiple non-image-forming light responses use non-rod, non-cone ocular photoreceptors in mice. An action spectrum for the PLR in rd/rd cl mice demonstrates that over the range 420-625 nm, this response is driven by a single opsin/vitamin A-based photopigment with peak sensitivity around 479 nm (opsin photopigment/OP479). These data represent the first functional characterization of a non-rod, non-cone photoreceptive system in the mammalian CNS.
引用
收藏
页码:621 / 626
页数:6
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