Enhanced photostability of ICG in close proximity to gold colloids

被引：31

作者：

Geddes, CD ^{[1
]}

Cao, HS ^{[1
]}

Lakowicz, JR ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Ctr Fluorescence Spect, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2003年 / 59卷 / 11期

关键词：

fluorescence; photostability; indocyanine green; gold colloids;

D O I：

10.1016/S1386-1425(03)00015-5

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Photobleaching of fluorophores frequently limits their delectability or observation time. We examined Indocyanine green (ICG) which is widely used in medical testing and is highly unstable. We showed that spatial localization of ICG near metallic gold colloids resulted in increased photostability. This suggests the use of fluorophore-metal conjugates in situations adversely affected by photobleaching. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：2611 / 2617

页数：7

共 32 条

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