Oxaziridine-mediated amination of primary amines: Scope and application to a one-pot pyrazole synthesis

被引：92

作者：

Armstrong, A ^{[1
]}

Jones, LH

Knight, JD

Kelsey, RD

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Pfizer Global R&D, Dept Discovery Chem, Sandwich CT13 9NJ, Kent, England

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 04期

关键词：

D O I：

10.1021/ol0474507

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Electrophilic amination of primary aliphatic and aromatic amines is reported using a diethylketomalonate-derived oxaziridine to afford the corresponding N-Boc hydrazines in good to excellent yields. The method allows a one-pot synthesis of pyrazoles from primary amines.

引用

页码：713 / 716

页数：4

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