Afut1, a retrotransposon-like element from Aspergillus fumigatus

被引：93

作者：

Neuveglise, C ^{[1
]}

Sarfati, J ^{[1
]}

Latge, JP ^{[1
]}

Paris, S ^{[1
]}

机构：

[1] INST PASTEUR,LAB ASPERGILLUS,F-75724 PARIS 15,FRANCE

来源：

NUCLEIC ACIDS RESEARCH | 1996年 / 24卷 / 08期

关键词：

D O I：

10.1093/nar/24.8.1428

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A repeated DNA sequence used for epidemiological studies of the human opportunistic pathogen Aspergillus fumigatus has been characterized. It is a retroelement of 6914 bp in length, bounded by long terminal repeats of 282 bp, with sequence and features characteristic of retroviruses and retrotransposons. A 5 bp duplication site was found at its borders. This element, designated Afut1, encodes amino acid sequences homologous to the reverse transcriptase, RNase H and endonuclease encoded by the pol genes of retroelements. Comparison of the peptidic sequences with other putative polypeptides of fungal LTR retrotransposons showed that Afut1 is a member of the gypsy group. This is the first report of a transposable element in A.fumigatus. Afut1 is a defective element: the putative coding domains contain multiple stop codons due exclusively to transitions from C:G to T:A.

引用

页码：1428 / 1434

页数：7

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