Suppressive effects of a herbal formula, TBL-1, on type II collagen-induced arthritis in DBA/1J mice

被引：7

作者：

Li, SH

Kobayashi, Y

Yamauchi, Y

Gonda, T

Tsunematsu, T

机构：

[1] SHIMANE MED UNIV,DEPT PHARMACOL,IZUMO,SHIMANE 693,JAPAN

[2] SHIMANE MED UNIV,INST EXPT ANIM,DEPT INTERNAL MED 3,IZUMO,SHIMANE 693,JAPAN

[3] SHIMANE INST HLTH SCI,IZUMO,SHIMANE,JAPAN

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1996年 / 23卷 / 03期

关键词：

arthritis; collagen; DBA/1J mice; immunoregulation; TBL-1;

D O I：

10.1111/j.1440-1681.1996.tb02602.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The effects of a formula of traditional Chinese medicine, TBL-1, on collagen-induced arthritis (CIA) were investigated in DBA/1J mice. 2. From 4 weeks after the first immunization with bovine type II collagen (CII), TBL-1 or indomethacin was administered orally for 13 weeks. 3. Clinical scores of CIA were decreased by both TBL-1 and indomethacin intervention compared with the control CII-immunized group. 4. Radiographic scores of phalangeal destruction were markedly improved by TBL-1 intervention (P<0.001), but indomethacin failed. 5. The suppressive effects of TBL-1, but not indomethacin, were manifested in reduced serum anti-CII antibody titres (P<0.001). 6. These findings suggest that TBL-1 may play a role in regulating some immune responses in the present arthritis model.

引用

页码：236 / 240

页数：5

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