Suppressive effects of a herbal formula, TBL-1, on type II collagen-induced arthritis in DBA/1J mice

被引:7
作者
Li, SH
Kobayashi, Y
Yamauchi, Y
Gonda, T
Tsunematsu, T
机构
[1] SHIMANE MED UNIV,DEPT PHARMACOL,IZUMO,SHIMANE 693,JAPAN
[2] SHIMANE MED UNIV,INST EXPT ANIM,DEPT INTERNAL MED 3,IZUMO,SHIMANE 693,JAPAN
[3] SHIMANE INST HLTH SCI,IZUMO,SHIMANE,JAPAN
关键词
arthritis; collagen; DBA/1J mice; immunoregulation; TBL-1;
D O I
10.1111/j.1440-1681.1996.tb02602.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. The effects of a formula of traditional Chinese medicine, TBL-1, on collagen-induced arthritis (CIA) were investigated in DBA/1J mice. 2. From 4 weeks after the first immunization with bovine type II collagen (CII), TBL-1 or indomethacin was administered orally for 13 weeks. 3. Clinical scores of CIA were decreased by both TBL-1 and indomethacin intervention compared with the control CII-immunized group. 4. Radiographic scores of phalangeal destruction were markedly improved by TBL-1 intervention (P<0.001), but indomethacin failed. 5. The suppressive effects of TBL-1, but not indomethacin, were manifested in reduced serum anti-CII antibody titres (P<0.001). 6. These findings suggest that TBL-1 may play a role in regulating some immune responses in the present arthritis model.
引用
收藏
页码:236 / 240
页数:5
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