Electrophysiological effects of felbamate

被引：6

作者：

Corradetti, R ^{[1
]}

Pugliese, AM ^{[1
]}

机构：

[1] Univ Florence, Dept Preclin & Clin Pharmacol Mario Aiazzi Mancin, I-50134 Florence, Italy

来源：

LIFE SCIENCES | 1998年 / 63卷 / 13期

关键词：

felbamate; antiepileptic drug; epilepsy; strychnine-insensitive glycine receptor; NMDA receptor; glutamate receptors; GABA receptors; sodium channels; calcium channels; long-term potentiation;

D O I：

10.1016/S0024-3205(98)00230-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Felbamate is a broad spectrum antiepileptic drug recently introduced into clinical practice for controlling seizures in patients affected by Lennox-Gastaut epilepsy, complex partial seizures or otherwise intractable epilepsies. However, the cellular mechanisms by which the drug exerts its anticonvulsant actions are not fully understood. The aim of the present article is to outline the possible mechanisms of action of felbamate as suggested by findings obtained with electrophysiological approaches.

引用

页码：1075 / 1088

页数：14

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