Abietane diterpenoids isolation from Plectranthus barbatus

被引：16

作者：

de Albuquerque, Roberto L. ^{[1
]}

Kentopff, Marta R. ^{[1
]}

Machado, Maria Iracema L. ^{[1
]}

Silva, Maria Goretti V. ^{[1
]}

Matos, Francisco Jose de A. ^{[1
]}

Morais, Selene M. ^{[2
]}

Braz Filho, Raimundo ^{[3
]}

机构：

[1] Univ Fed Do Ceara, Dept Quim & Fisicoquim, Dept Quim Organ & Inorgan, BR-60451970 Fortaleza, Ceara, Brazil

[2] Univ Estadual Ceara, BR-60740903 Fortaleza, Ceara, Brazil

[3] Univ Estadual Norte Fluminese, Ctr Ciencia & Tecnol, Setor Quim Prod Nat, BR-28013600 Campos Dos Goytacazes, RJ, Brazil

来源：

QUIMICA NOVA | 2007年 / 30卷 / 08期

关键词：

Plectranthus barbatus; labiatae; abietane diterpenoids;

D O I：

10.1590/S0100-40422007000800016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Plectranthus barbatus is largely used in the Northeast region of Brazil by the local population for treatment of digestive problems As substitute of boldo (Pneumus boldus). Phytochemical analysis of the leaf extracts of Plectranthus barbatus (Labiatae) cultivated in this region yielded two abietane diterpenoids, cyclobubatusin (1) and barbatusin (2) and a new one named 7 beta-acetyl-12-deacetoxycyclobutatusin (3). The structures of the isolated compounds were established by spectral analysis, using mainly mass spectra and H-1 and (CNMR)-C-13 (1D and 2D). These procedures permitted the assignment of all chemical shifts in the diterpenoids.

引用

页码：1882 / 1886

页数：5

共 25 条

[1] Chemistry of the genus Plectranthus [J].

Abdel-Mogib, M ;

Albar, HA ;

Batterjee, SM .

MOLECULES, 2002, 7 (02) :271-301

[2]

ALBUQUERQUE RL, 2006, FLAVOUR FRAG J, V22, P24

[3]

ANDREW HJ, 1974, J AM CHEM SOC, V23, P580

[4] Antiepileptic effect of Plectranthus amboinicus (lour.) Spreng. (french marjoram) [J].

Buznego, MT ;

Pérez-Saad, H .

REVISTA DE NEUROLOGIA, 1999, 29 (04) :388-389

[5] Effect of abietane diterpenes from Plectranthus grandidentatus on T- and B-lymphocyte proliferation [J].

Cerqueira, F ;

Cordeiro-Da-Silva, A ;

Gaspar-Marques, C ;

Simoes, F ;

Pinto, MMM ;

Nascimento, MSJ .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (01) :217-223

[6]

Costa Maria do Carmo C. D., 2003, Acta Farmaceutica Bonaerense, V22, P155

[7] THE WATER EXTRACT OF COLEUS-BARBATUS BENTH DECREASES GASTRIC-SECRETION IN RATS [J].

FISCHMAN, LA ;

SKORUPA, LA ;

SOUCCAR, C ;

LAPA, AJ .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 1991, 86 :141-143

[8] First synthesis of 1,9-dideoxyforskolin from ptychantin A [J].

Hagiwara, H ;

Takeuchi, F ;

Hoshi, T ;

Suzuki, T ;

Hashimoto, T ;

Asakawa, Y .

TETRAHEDRON LETTERS, 2003, 44 (11) :2305-2306

[9]

Harley R. M., 1992, ADV LABIATAE SCI

[10] Isolation, structure, and biological activities of long-chain catechols of Plectranthus sylvestris (Labiatae) [J].

Juch, M ;

Ruedi, P .

HELVETICA CHIMICA ACTA, 1997, 80 (02) :436-448

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