Application of the extremum stack to neurological MRI

The extremum stack, as proposed by Koenderink, is a multiresolution image description and segmentation scheme which examines intensity extrema (minima and maxima) as they move and merge through a series of progressively isotropically diffused images known as scale space. Such a data-driven approach is attractive because it is claimed to be a generally applicable and natural method of image segmentation, The performance of the extremum stack is evaluated here using the case of neurological magnetic resonance imaging data as a specific example, and means of improving its performance proposed, It is confirmed experimentally that the extremum stack has the desirable property of being shift-, scale-, and rotation-invariant, and produces natural results for many compact regions of anatomy, It handles elongated objects poorly, however, and subsections of regions may merge prematurely before each region is represented as a single node. It is shown that this premature merging can often be avoided by the application of either a variable conductance-diffusing preprocessing step, or more effectively, the use of an adaptive variable conductance diffusion method within the extremum stack itself in place of the isotropic Gaussian diffusion proposed by Koenderink.