Discordant HHV8 detection in a young HIV-negative patient with Kaposi's sarcoma and sarcoidosis

被引：15

作者：

di Gennaro, G

Canzonieri, V

Schioppa, O

Nasti, G

Carbone, A

Tirelli, U

机构：

[1] Natl Canc Inst, Div Med Oncol A, I-33081 Aviano, Italy

[2] Natl Canc Inst, Div Pathol, Aviano, Italy

来源：

CLINICAL INFECTIOUS DISEASES | 2001年 / 32卷 / 07期

关键词：

D O I：

10.1086/319603

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human herpesvirus 8 (HHV8), which has been suggested as the causal agent of Kaposi's sarcoma (KS), has also been implicated in the pathogenesis of sarcoidosis. We describe a patient affected concomitantly by sarcoidosis and KS. HHV8 sequences were detected with PCR only on KS lesions, whereas sarcoid tissues did not harbor HHV8 DNA. Immune dysfunction related to sarcoidosis may have facilitated the oncogenic role of HHV8 and the development of KS.

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页码：1100 / 1102

页数：3

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