H-phosphonate derivatives as novel peptide deformylase inhibitors

被引：27

作者：

Hu, YJ ^{[1
]}

Rajagopalan, PTR ^{[1
]}

Pei, DH ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(98)00443-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Peptide deformylase catalyzes the removal of the N-terminal formyl group from nascent polypeptides during prokaryotic protein maturation and is essential for bacterial survival. Its absence from eukaryotic organisms makes it an attractive target for designing novel antibacterial agents. Peptidyl H-phosphonates were synthesized and shown to be competitive inhibitors of the deformylase. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2479 / 2482

页数：4

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