Familial Alzheimer disease:: Decreases in CSF Aβ42 levels precede cognitive decline

被引：72

作者：

Moonis, M

Swearer, JM

Dayaw, MPE

St George-Hyslop, P

Rogaeva, E

Kawarai, T

Pollen, DA

机构：

[1] Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA 01655 USA

[2] Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, Canada

[3] Univ Toronto, Dept Med, Toronto, ON, Canada

[4] Toronto Western Hosp, Inst Res, Movement Disorders Ctr, Toronto, ON M5T 2S8, Canada

[5] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada

来源：

NEUROLOGY | 2005年 / 65卷 / 02期

关键词：

D O I：

10.1212/01.wnl.0000171397.32851.bc

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

CSF amyloid beta-peptide 42 (A beta(42)) levels in presymptomatic subjects with pathogenic mutations in the PS1 gene are significantly lower than in an age-matched control group. Consequently, in these subjects, there is a window of opportunity estimated as at least 4 to 12 years to evaluate the ability of any putative prophylactic therapy to decrease, arrest, or reverse abnormalities in A beta(42) metabolism many years before clinical symptoms of Alzheimer disease are otherwise likely to occur.

引用

页码：323 / 325

页数：3

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