Familial Alzheimer disease:: Decreases in CSF Aβ42 levels precede cognitive decline

被引:72
作者
Moonis, M
Swearer, JM
Dayaw, MPE
St George-Hyslop, P
Rogaeva, E
Kawarai, T
Pollen, DA
机构
[1] Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA 01655 USA
[2] Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
[3] Univ Toronto, Dept Med, Toronto, ON, Canada
[4] Toronto Western Hosp, Inst Res, Movement Disorders Ctr, Toronto, ON M5T 2S8, Canada
[5] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada
关键词
D O I
10.1212/01.wnl.0000171397.32851.bc
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
CSF amyloid beta-peptide 42 (A beta(42)) levels in presymptomatic subjects with pathogenic mutations in the PS1 gene are significantly lower than in an age-matched control group. Consequently, in these subjects, there is a window of opportunity estimated as at least 4 to 12 years to evaluate the ability of any putative prophylactic therapy to decrease, arrest, or reverse abnormalities in A beta(42) metabolism many years before clinical symptoms of Alzheimer disease are otherwise likely to occur.
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页码:323 / 325
页数:3
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