Synthesis of artificial glycoconjugate polymers carrying biologically active trisaccharides with α-D-galactopyranosyl (1→3) and (1→4)-linkage

被引：34

作者：

Nishida, Y

Dohi, H

Uzawa, H

Kobayashi, K

机构：

[1] Nagoya Univ, Grad Sch Engn, Dept Mol Design & Engn, Chikusa Ku, Nagoya, Aichi 4648603, Japan

[2] Natl Inst Mat & Chem Res, Tsukuba, Ibaraki 305, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 47期

关键词：

polymers; biologically active compounds; glycosidation; regiospecificity;

D O I：

10.1016/S0040-4039(98)01897-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from p-nitrophenyl-beta-lactoside, two types of neoglycoconjugate carrying either a trisaccharide segment of globotriaosyl ceramide (Gb3) or its regioisomeric Gal alpha 1,3Gal beta 1,4Glc were synthesized via a common intermediate. The former polymer carrying the Gb3 trisaccharide showed strong neutralization activity against Shiga-like toxin-I in the assay using human ACHN cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：8681 / 8684

页数：4

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