Effect of glycosylation on cloned ANF-sensitive guanylyl cyclase

被引：13

作者：

Heim, JM ^{[1
]}

Singh, SJ ^{[1
]}

Gerzer, R ^{[1
]}

机构：

[1] DLR,INST LUFT & RAUMFAHRTMED,D-51147 COLOGNE,GERMANY

来源：

LIFE SCIENCES | 1996年 / 59卷 / 04期

关键词：

guanylyl cyclase; atrial natriuretic peptide; urodilatin; cyclic GMP;

D O I：

10.1016/0024-3205(96)00306-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cloned ANF-sensitive guanylyl cyclase (GC-A) and ANF-sensitive guanylyl cyclase from adrenal cortex differ in their sensitivity to the ANF analogs atriopeptin 1 and urodilatin. To test the hypothesis that these differences are due to different glycosylation, we investigated the effect of the N-glycosylation inhibitor tunicamycin on GC-A. Tunicamycin altered the response of GC-A to atriopeptin 1 and urodilatin, whereas the sensitivity to ANF remained unchanged. These data indicate that agonist specificities of different ANF-sensitive guanylyl cyclases are influenced by carbohydrate moieties.

引用

页码：PL61 / PL68

页数：8

共 20 条

[1] INHIBITION OF ADENYLYL CYCLASE ACTIVITY IN RAT CORPORA LUTEAL TISSUE BY GLYCOPEPTIDES OF HUMAN CHORIONIC-GONADOTROPIN AND THE ALPHA-SUBUNIT OF HUMAN CHORIONIC-GONADOTROPIN [J].