Histone lysine methylation: a signature for chromatin function

被引：526

作者：

Sims, RJ

Nishioka, K

Reinberg, D ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Howard Hughes Med Inst, Div Nucle Acids Enzymol,Dept Biochem, Piscataway, NJ 08854 USA

[2] Natl Inst Genet, Dept Dev Genet, Mishima, Shizuoka 4118540, Japan

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 11期

关键词：

D O I：

10.1016/j.tig.2003.09.007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The rapid progress in deciphering the processes of covalent histone modifications has broadened our understanding of transcriptional regulation. Histone lysine methylation, along with DNA methylation, establishes the framework for long-term epigenetic maintenance. Recent studies of the mechanisms of specific histone lysine methylation have revealed a complex process that controls aspects of short- and long-term transcriptional regulation, in addition to the propagation of bulk chromosome structure and stability. In this article, we review the functional properties of histone lysine methylation and the enzymes that catalyze this covalent modification.

引用

页码：629 / 639

页数：11

共 99 条

[1] Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
Ayton, PM
Cleary, ML
[J]. ONCOGENE, 2001, 20 (40) : 5695 - 5707
[2] Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation
Ayyanathan, K
Lechner, MS
Bell, P
Maul, GG
Schultz, DC
Yamada, Y
Tanaka, K
Torigoe, K
Rauscher, FJ
[J]. GENES & DEVELOPMENT, 2003, 17 (15) : 1855 - 1869
[3] RETRACTED: Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1 (Retracted article. See vol. 521, pg. 110, 2015)
Beisel, C
Imhof, A
Greene, J
Kremmer, E
Sauer, F
[J]. NATURE, 2002, 419 (6909) : 857 - 862
[4] DNA methylation patterns and epigenetic memory
Bird, A
[J]. GENES & DEVELOPMENT, 2002, 16 (01) : 6 - 21
[5] Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
Boggs, BA
Cheung, P
Heard, E
Spector, DL
Chinault, AC
Allis, CD
[J]. NATURE GENETICS, 2002, 30 (01) : 73 - 76
[6] Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae
Briggs, SD
Bryk, M
Strahl, BD
Cheung, WL
Davie, JK
Dent, SYR
Winston, F
Allis, CD
[J]. GENES & DEVELOPMENT, 2001, 15 (24) : 3286 - 3295
[7] Role of histone H3 lysine 27 methylation in polycomb-group silencing
Cao, R
Wang, LJ
Wang, HB
Xia, L
Erdjument-Bromage, H
Tempst, P
Jones, RS
Zhang, Y
[J]. SCIENCE, 2002, 298 (5595) : 1039 - 1043
[8] Maintenance of stable heterochromatin domains by dynamic HP1 binding
Cheutin, T
McNairn, AJ
Jenuwein, T
Gilbert, DM
Singh, PB
Misteli, T
[J]. SCIENCE, 2003, 299 (5607) : 721 - 725
[9] Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal polycomb sites
Czermin, B
Melfi, R
McCabe, D
Seitz, V
Imhof, A
Pirrotta, V
[J]. CELL, 2002, 111 (02) : 185 - 196
[10] Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6
Dover, J
Schneider, J
Tawiah-Boateng, MA
Wood, A
Dean, K
Johnston, M
Shilatifard, A
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (32) : 28368 - 28371

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