Walking behaviour and glycemic control in type 2 diabetes: Seasonal and gender differences-study design and methods

Background: The high glucose levels typically occurring among adults with type 2 diabetes contribute to blood vessel injury and complications such as blindness, kidney failure, heart disease, and stroke. Higher physical activity levels are associated with improved glycemic control, as measured by hemoglobin AIC. A 1% absolute increase in AIC is associated with an 18% increased risk for heart disease or stroke. Among Canadians with type 2 diabetes, we postulate that declines in walking associated with colder temperatures and inclement weather may contribute to annual post- winter increases in AIC levels. Methods: During this prospective cohort study being conducted in Montreal, Quebec, Canada, 100 men and 100 women with type 2 diabetes will undergo four assessments ( once per season) over a one- year period of observation. These assessments include ( 1) use of a pedometer with a concealed viewing window for a two- week period to measure walking ( 2) a study centre visit during which venous blood is sampled for AIC, anthropometrics are assessed, and questionnaires are completed for measurement of other factors that may influence walking and/ or AIC ( e. g. food frequency, depressive symptomology, medications). The relationship between spring- fall AIC difference and winter-summer difference in steps/ day will be examined through multivariate linear regression models adjusted for possible confounding. Interpretation of findings by researchers in conjunction with potential knowledge " users" ( e. g. health professionals, patient groups) will guide knowledge translation efforts. Discussion: Although we cannot alter weather patterns to favour active lifestyles, we can design treatment strategies that take seasonal and weather- related variations into account. For example, demonstration of seasonal variation of AIC levels among Canadian men and women with T2D and greater understanding of its determinants could lead to ( 1) targeting physical activity levels to remain at or exceed peak values achieved during more favourable weather conditions. Strategies may include shifting to indoor activities or adapting to less favourable conditions ( e. g. appropriate outdoor garments, more frequent but shorter duration periods of activity) ( 2) increasing dose/ number of glucose- lowering medications during the winter and reducing these during the summer, in anticipation of seasonal variations ( 3) examining the impact of bright light therapyon activity and AIC among T2D patients with an increase in depressive symptomology when sunlight hours decline.