SDF-1 and CCR5 genes polymorphism in patients with head and neck cancer

被引：28

作者：

Khademi, Bijan ^{[1
]}

Razmkhah, Mahboobeh ^{[1
]}

Erfani, Nasrollah ^{[1
]}

Gharagozloo, Marjan ^{[2
]}

Ghaderi, Abbas ^{[1
]}

机构：

[1] Shiraz Univ Med Sci, Shiraz Inst Canc Res, Dept ENT, Shiraz, Iran

[2] Shiraz Univ Med Sci, Dept Immunol, Shiraz, Iran

来源：

PATHOLOGY & ONCOLOGY RESEARCH | 2008年 / 14卷 / 01期

关键词：

head and neck cancer; SDF-1; CCR5; polymorphism; metastasis;

D O I：

10.1007/s12253-008-9007-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The frequency of SDF1-3'A and CCR5 Delta 32 in patients with head and neck cancer were determined in this study. The frequencies of alleles and genotypes of SDF-1 and CCR5 were assessed by PCR method in 156 patients with malignant head and neck cancer, 125 (80.1%) cases with squamous cell carcinoma and 31 (19.9%) cases with salivary gland tumors and compared with 262 age-sex matched healthy control individuals. SDF-1 genotypes in patients with SCC of head and neck, but not with salivary gland tumors, showed a statistically significant difference compared to the normal group (P < 0.005 for SCC and P = 0.3 for salivary gland tumors). There were no significant differences in the frequencies of SDF1-3'A allele, CCR5 genotypes and alleles between patients and controls. Based on the present study SDF1-3A may be associated with the susceptibility of patients to SCC of head and neck cancer.

引用

页码：45 / 50

页数：6

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