Treatment of sialorrhea with glycopyrrolate - A double-blind, dose-ranging study

被引：144

作者：

Mier, RJ ^{[1
]}

Bachrach, SJ ^{[1
]}

Lakin, RC ^{[1
]}

Barker, T ^{[1
]}

Childs, J ^{[1
]}

Moran, M ^{[1
]}

机构：

[1] Alfred I duPont Hosp Children, Wilmington, DE USA

来源：

ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE | 2000年 / 154卷 / 12期

关键词：

D O I：

10.1001/archpedi.154.12.1214

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective: To determine the safety and efficacy of glycopyrrolate in the treatment of developmentally disabled children with sialorrhea. Design: Placebo-controlled, double-blind, crossover dose-ranging study. Setting: Outpatient facilities in 2 pediatric hospitals. Patients: Thirty-nine children with bo th developmental disabilities and excessive and bothersome sialorrhea. Main Outcome Measures: Parent and investigator evaluation of change in sialorrhea and adverse effects. Results: Glycopyrrolate in doses of 0.10 mg/kg per dose is effective at controlling sialorrhea. Even at low doses, 20% of children may exhibit adverse effects severe enough to require discontinuation. Conclusions: Glycopyrrolate is effective in the control of excessive sialorrhea in children with developmental disabilities. Approximately 20% of children given glycopyrrolate may experience substantial adverse effects, enough to require discontinuation of medication.

引用

页码：1214 / 1218

页数：5

共 13 条

[1] Use of glycopyrrolate and other anticholinergic medications for sialorrhea in children with cerebral palsy [J].