Free radical scavenging and hepatoprotective activity of jigrine against galactosamine induced hepatopathy in rats

被引：38

作者：

Najmi, AK ^{[1
]}

Pillai, KK

Pal, SN

Aqil, A

机构：

[1] Jamia Hamdard, Fac Pharm, Dept Pharmacol, New Delhi 110062, India

[2] Jamia Hamdard, Fac Pharm, Dept Pharmaceut, New Delhi 110062, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 97卷 / 03期

关键词：

jigrine; Unani medicine; galactosamine; hepatopathy; silymarin; DPPH;

D O I：

10.1016/j.jep.2004.12.016

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Jigrine a polypharmaceutical herbal hepatoprotective formulation containing aqueous extracts of 14 medicinal plants is used in Indian system of medicine (Unani). Jigrine was evaluated for its hepatoprotective activity against galactosamine induced hepatopathy in rats. Galactosamine induced hepatotoxicity resembles human viral hepatitis. Biochemical parameters like AST, ALT and urea in serum, TBARS and glutathione in liver and whole blood glutathione were estimated to assess liver function. DPPH-free radical scavenging activity of jigrine was also evaluated. Biochemical data exhibited significant hepatoprotective activity of jigrine against galactosamine. Silymarin used as reference standard also exhibited significant hepatoprotective activity against galactosamine. The biochemical observations were supplemented with histopathological examination of rat liver sections. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：521 / 525

页数：5

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