Polyphenolic compounds from Geranium pratense and their free radical scavenging activities

被引:37
作者
Akdemir, ZS [1 ]
Tatli, II
Saracoglu, I
Ismailoglu, UB
Sahin-Erdemli, I
Çalis, I
机构
[1] Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey
[2] Hacettepe Univ, Fac Pharm, Dept Pharmacol, TR-06100 Ankara, Turkey
关键词
Geranium pratense subsp finitimum (Woronow) Knuth; Geraniaceae; flavonoid; myricetin 3-O-(2 '-O-galloyl)-beta-D-glucopyranoside; (-)-6-chloroepicatechin; free radical scavenger;
D O I
10.1016/S0031-9422(00)00367-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two new polyphenolic compounds, myricetin 3-O-(2"-O-galloyl)-beta -D-glucopyranoside and (-)-6-chloroepicatechin, were isolated from the aerial parts of Geranium pratense subsp. finitimum (Woronow) Knuth, along with three known polyphenolic compounds [quercetin 3-O-(2"-O-galloyl)-beta -D-glucopyranoside, quercetin 3-O-(2"-O-galloyl)-beta -D-galactopyranoside, methyl gallate] and tryptophan. Quercetin 3-O-beta -D-glucopyranoside, quercetin 3-O-beta -D-galactopyranoside, quercetin 3-O-(2"-O-galloyl)-beta -D-glucopyranoside and quercetin 3-O-(2"-O-galloyl)-beta -D-galactopyranoside were found to be effective against free radical induced impairment of endothelium-dependent relaxation in isolated rat aorta. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:189 / 193
页数:5
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