Thymic Stromal Lymphopoietin Is a Key Mediator of Breast Cancer Progression

被引：88

作者：

Olkhanud, Purevdorj B. ^{[1
]}

Rochman, Yrina ^{[2
]}

Bodogai, Monica ^{[1
]}

Malchinkhuu, Enkhzol ^{[1
]}

Wejksza, Katarzyna ^{[1
]}

Xu, Mai ^{[1
]}

Gress, Ronald E. ^{[3
]}

Hesdorffer, Charles ^{[4
]}

Leonard, Warren J. ^{[2
]}

Biragyn, Arya ^{[1
]}

机构：

[1] NIA, Immunotherapeut Unit, Lab Mol Biol & Immunol, Baltimore, MD 21224 USA

[2] NHLBI, Lab Mol Immunol, Ctr Immunol, NIH, Bethesda, MD 20892 USA

[3] NCI, Expt Transplantat & Immunol Branch, Bethesda, MD 20892 USA

[4] NIA, Clin Res Branch, Baltimore, MD 21224 USA

来源：

JOURNAL OF IMMUNOLOGY | 2011年 / 186卷 / 10期

基金：

美国国家卫生研究院;

关键词：

REGULATORY T-CELLS; CHEMOKINE RECEPTORS; AIRWAY HYPERREACTIVITY; TSLP; INFLAMMATION; EXPRESSION; INDUCE; ASTHMA; LUNG; CCR4;

D O I：

10.4049/jimmunol.1100463

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammation is a double-edged sword that can promote or suppress cancer progression. In this study, we report that thymic stromal lymphopoietin (TSLP), an IL-7-like type 1 inflammatory cytokine that is often associated with the induction of Th2-type allergic responses in the lungs, is also expressed in human and murine cancers. Our studies with murine cancer cells indicate that TSLP plays an essential role in cancer escape, as its inactivation in cancer cells alone was sufficient to almost completely abrogate cancer progression and lung metastasis. The cancer-promoting activity of TSLP primarily required signaling through the TSLP receptor on CD4(+) T cells, promoting Th2-skewed immune responses and production of immunosuppressive factors such as IL-10 and IL-13. Expression of TSLP therefore may be a useful prognostic marker, and its targeting could have therapeutic potential. The Journal of Immunology, 2011, 186: 5656-5662.

引用

页码：5656 / 5662

页数：7

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