The phospholipase D superfamily as therapeutic targets

被引：150

作者：

Frohman, Michael A. ^{[1
,2
]}

机构：

[1] SUNY Stony Brook, Dept Pharmacol Sci, Stony Brook, NY 11794 USA

[2] SUNY Stony Brook, Ctr Mol Med 438, Ctr Dev Genet, Stony Brook, NY 11794 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2015年 / 36卷 / 03期

关键词：

PLD1; PLD2; small-molecule inhibitors; cancer; thrombosis; autoimmune disease; INDUCED SUPEROXIDE GENERATION; ADRENAL GLOMERULOSA CELLS; PHOSPHATIDIC-ACID; MOLECULAR-MECHANISMS; LYMPHOCYTE ADHESION; THROMBUS FORMATION; MOUSE NEUTROPHILS; RUFFLE FORMATION; PLASMA-MEMBRANE; INFLUENZA-VIRUS;

D O I：

10.1016/j.tips.2015.01.001

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The phospholipase D (PLD) lipid-signaling enzyme superfamily has long been studied for its roles in cell communication and a wide range of cell biological processes. With the advent of loss-of-function genetic mouse models that have revealed that PLD1 and PLD2 ablation is overtly tolerable, small-molecule PLD1/2 inhibitors that do not cause unacceptable clinical toxicity, a PLD2 polymorphism that has been linked to altered physiology, and growing delineation of processes that are subtly altered in mice lacking PLD1/2 activity, the stage is being set for assessment of PLD1/2 inhibition for therapeutic purposes. Based on findings to date, PLD1/2 inhibition may be of more utility in acute rather than chronic settings, although this generalization will depend on the specific risks and benefits in each disease setting.

引用

页码：137 / 144

页数：8

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