Polyoxygenated steroids from the gorgonian Isis hippuris

被引：41

作者：

Chao, CH

Huang, LF

Yang, YL

Su, JH

Wang, GH

Chiang, MY

Wu, YC

Dai, CF

Sheu, JH ^{[1
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Resources, Kaohsiung 804, Taiwan

[2] Hsing Kuo Univ, Ctr Gen Educ, Tainan 709, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[4] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[5] Natl Taiwan Univ, Inst Oceanog, Taipei 106, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 06期

关键词：

D O I：

10.1021/np050033y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eleven new hippuristanols (1-4, 7-9, and 11-14), along with eight known metabolites (5, 6, 10, and 15-19), have been isolated from the gorgonian coral Isis hippuris. Single-crystal X-ray diffraction analyses supported the structure elucidation of known steroids 5 and 10. The absolute structures of hippuristanols were established by application of modified Mosher's method on 19. Compounds 14-19 have been found to exhibit significant cytotoxicity against several cancer cell lines.

引用

页码：880 / 885

页数：6

共 13 条

[1]

ALLEY MC, 1988, CANCER RES, V48, P589

[2] New cytotoxic steroids from the gorgonian Isis hippuris.: Structure-activity studies [J].