In vitro release of cytarabine from swellable matrices of CnEmCn triblock copolymers

被引：3

作者：

Ameri, M

Collett, JH

Attwood, D ^{[1
]}

Booth, C

机构：

[1] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester Polymer Ctr, Manchester M13 9PL, Lancs, England

[2] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

JOURNAL OF CONTROLLED RELEASE | 1998年 / 56卷 / 1-3期

基金：

英国工程与自然科学研究理事会;

关键词：

swellable matrices; block copolymers; cytarabine; hydrophilic matrix; release mechanism;

D O I：

10.1016/S0168-3659(98)00064-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Matrices loaded with cytarabine were prepared by compression of the tailor made triblock copolymers C17E227C17 and C17E454C17 (where C=methylene and E=oxyethylene). Observations of the swelling characteristics of copolymer matrices on immersion in distilled water indicated an increase in the thickness of the gel layer around the matrices following ingress of water into the matrices. The in vitro release of cytarabine was characterised from matrices of different molar mass and with different known drug loadings. The release of cytarabine from the copolymer matrices was predominantly by a Fickian diffusion mechanism; the release rate was dependent on drug loading and independent of copolymer molar mass. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 6

页数：6

共 16 条

[1] LOW-DOSE CYTOSINE-ARABINOSIDE IN RELAPSED ACUTE LYMPHOCYTIC-LEUKEMIA [J].