Review - What is the role of melatonin within the anterior pituitary?

被引：38

作者：

Hazlerigg, DG ^{[1
]}

机构：

[1] Univ Aberdeen, Anim Biol Grp, Dept Agr & Forestry, ACERO, Aberdeen AB24 5UA, Scotland

来源：

JOURNAL OF ENDOCRINOLOGY | 2001年 / 170卷 / 03期

关键词：

D O I：

10.1677/joe.0.1700493

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The pineal hormone, melatonin, is uniquely defined by its role as hormonal time, but the processes whereby cells extract temporal information from the melatonin signal are not understood. Melatonin receptors are expressed in the pars tuberalis (PT) and, during fetal and perinatal life, in the pars distalis (PD). Functional studies suggest that the PT mediates the seasonal effects of melatonin on prolactin secretion, whilst the PD may be involved in photoperiodic programming of the developing gonadotrophic axis. To understand these effects at the cellular level we need to know the phenotype of melatonin-responsive cells. This review summarises current understanding in this area, and highlights present shortcomings. A case is presented for exploring the hypothesis that there is a functional association between melatonin receptor expression and cell differentiation in the anterior pituitary.

引用

页码：493 / 501

页数：9

共 73 条

[1] Jet-lag and shift work: (2) therapeutic use of melatonin [J].

Arendt, J .

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1999, 92 (08) :402-405

[2]

AUBERT ML, 1989, RES PERINATAL MED, V9, P155

[3]

Barrett P, 1999, BIOL SIGNAL RECEPT, V8, P6

[4]

BARTNESS TJ, 1993, J PINEAL RES, V15, P161

[5] MAMMALIAN PINEAL MELATONIN - A CLOCK FOR ALL SEASONS [J].

BARTNESS, TJ ;

GOLDMAN, BD .

EXPERIENTIA, 1989, 45 (10) :939-945

[6] Seasonal neuroplasticity in the songbird telencephalon: A role for melatonin [J].

Bentley, GE ;

Van't Hof, TJ ;

Ball, GF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (08) :4674-4679

[7] PARS TUBERALIS-SPECIFIC CELLS IN THE OVINE PITUITARY DO EXPRESS THE COMMON ALPHA-CHAIN OF GLYCOPROTEIN HORMONES - AN IN-SITU HYBRIDIZATION AND IMMUNOCYTOCHEMICAL STUDY [J].

BOCKERS, TM ;

BOCKMANN, J ;

FAUTECK, JD ;

KREUTZ, MR ;

BOCK, R ;

WITTKOWSKI, W .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1994, 131 (05) :540-546

[8] Thyrotropin expression in hypophyseal pars tuberalis-specific cells is 3,5,3'-triiodothyronine, thyrotropin-releasing hormone, and Pit-1 independent [J].

Bockmann, J ;

Bockers, TM ;

Winter, C ;

Wittkowski, W ;

Winterhoff, H ;

Deufel, T ;

Kreutz, MR .

ENDOCRINOLOGY, 1997, 138 (03) :1019-1028

[9] Short photoperiod-dependent down-regulation of thyrotropin-alpha and -beta in hamster pars tuberalis-specific cells is prevented by pinealectomy [J].

Bockmann, J ;

Bockers, TM ;

Vennemann, B ;

Niklowitz, P ;

Muller, J ;

Wittkowski, W ;

Sabel, B ;

Kreutz, MR .

ENDOCRINOLOGY, 1996, 137 (05) :1804-1813

[10]

Brydon L, 1999, ADV EXP MED BIOL, V460, P215

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