The role of cytotoxicity in lymphocyte homeostasis

被引：45

作者：

de Saint Basile, G ^{[1
]}

Fischer, A ^{[1
]}

机构：

[1] Hop Necker Enfants Malad, INSERM, U429, F-75015 Paris, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(00)00257-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several human inherited immune disorders lead to the same fatal lymphoproliferative syndrome, called the hemophagocytic syndrome. Through defective perforin expression or transport, these disorders highlight the determinant role of the secretory cytotoxic pathway in the regulation of the immune response and in lymphocyte homeostasis. In addition, new effectors of this secretory pathway have been identified.

引用

页码：549 / 554

页数：6

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