Marked potentiation of activity of β-lactams against methicillin-resistant Staphylococcus aureus by corilagin

被引：104

作者：

Shimizu, M

Shiota, S

Mizushima, T

Ito, H

Hatano, T

Yoshida, T

Tsuchiya, T

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Dept Microbiol, Okayama 7008530, Japan

[2] Okayama Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Okayama 7008530, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 11期

关键词：

D O I：

10.1128/AAC.45.11.3198-3201.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We found that an extract of Aretostaphylos uva-ursi markedly reduced the MICs of beta -lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various beta -lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.

引用

页码：3198 / 3201

页数：4

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