Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells

被引：101

作者：

Locatelli, Claudriana ^{[3
]}

Rosso, Rober

Santos-Silva, Maria C. ^{[2
]}

de Souza, Camila A. ^{[2
]}

Licinio, Marley A.

Leal, Paulo

Bazzo, Maria L. ^{[2
]}

Yunes, Rosendo A.

Creczynski-Pasa, Tania B. ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Dept Ciencias Farmaceut, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Anal Clin, BR-88040900 Florianopolis, SC, Brazil

[3] Univ Contestado, BR-89500000 Cacador, SC, Brazil

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 07期

关键词：

gallic acid ester derivatives; leukemia; apoptosis; lipophilicity; NF-kappa B; GSH; oxidative stress;

D O I：

10.1016/j.bmc.2008.01.049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Gallic acid and gallates with the same number of hydroxyl groups and varying the length of the side carbon chain, with respective lipophilicity being defined through the C logP values, were examined for their ability to induce apoptosis (through the DNA ladder fragmentation pattern), mitochondrial and cytoplasmic GSH depletion and NF-kappa B activation in murine lymphoblastic L1210 leukemia cells. A relationship between cytotoxic effect and a limited degree of lipophilicity was observed. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：3791 / 3799

页数：9

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