Understanding the Lethal Variant of Prostate Cancer: Power of Examining Extremes

被引：106

作者：

Aparicio, Ana ^{[1
]}

Logothetis, Christopher J. ^{[1
]}

Maity, Sankar N. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, David H Koch Ctr Appl Res Genitourinary Canc, Unit 0018 6, Houston, TX 77030 USA

来源：

CANCER DISCOVERY | 2011年 / 1卷 / 06期

关键词：

MOLECULAR CHARACTERIZATION; AURORA KINASES; INHIBITOR;

D O I：

10.1158/2159-8290.CD-11-0259

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Small cell prostate carcinoma is a lethal variant of castration-resistant prostate cancer. Beltran and colleagues identified overexpression and amplification of both aurora kinase A (AURKA) and the MYCN protooncogene in the small cell prostate carcinomas and propose Aurora kinase A as a potential therapeutic target in this disease subset. Cancer Discovery; 1(6); 466-68. (C) 2011 AACR.

引用

页码：466 / 468

页数：3

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