HIV: The deadly passenger in dendritic cells

被引：34

作者：

Rowland-Jones, SL ^{[1
]}

机构：

[1] John Radcliffe Hosp, Inst Mol Med, Human Immunol Unit, Oxford OX3 9DS, England

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 07期

关键词：

D O I：

10.1016/S0960-9822(99)80155-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A picture is emerging of how HIV subverts a normal immunological surveillance mechanism to establish primary infection. This involves the infection of dendritic cells at mucosal surfaces: as these cells then mature, they transport the virus to lymphoid tissue, where viral replication begins and infection of CD4(+) T cells occurs.

引用

页码：R248 / R250

页数：3

共 11 条

[1] New insights into the mobilization and phagocytic activity of dendritic cells [J].

Austyn, JM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1287-1292

[2] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[3] HIV: Dendritic cells as embers for the infectious fire [J].

Clark, EA .

CURRENT BIOLOGY, 1996, 6 (06) :655-657

[4] Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites [J].

Dieu, MC ;

Vanbervliet, B ;

Vicari, A ;

Bridon, JM ;

Oldham, E ;

Aït-Yahia, S ;

Brière, F ;

Zlotnik, A ;

Lebecque, S ;

Caux, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (02) :373-386

[5] Immature dendritic cells selectively replicate macrophagetropic (M-tropic) human immunodeficiency virus type 1, while mature cells efficiently transmit both M- and T-Tropic virus to T cells [J].

Granelli-Piperno, A ;

Delgado, E ;

Finkel, V ;

Paxton, W ;

Steinman, RM .

JOURNAL OF VIROLOGY, 1998, 72 (04) :2733-2737

[6] Virus replication begins in dendritic cells during the transmission of HIV-1 from mature dendritic cells to T cells [J].

Granelli-Piperno, A ;

Finkel, V ;

Delgado, E ;

Steinman, RM .

CURRENT BIOLOGY, 1999, 9 (01) :21-29

[7] The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses [J].

Kalams, SA ;

Walker, BD .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (12) :2199-2204

[8] Bone-marrow-derived dendritic cells and the pathogenesis of AIDS [J].

Knight, SC .

AIDS, 1996, 10 (08) :807-817

[9] THE ROLE OF CD40 AND CD80 ACCESSORY CELL MOLECULES IN DENDRITIC CELL-DEPENDENT HIV-1 INFECTION [J].

PINCHUK, LM ;

POLACINO, PS ;

AGY, MB ;

KLAUS, SJ ;

CLARK, EA .

IMMUNITY, 1994, 1 (04) :317-325

[10] A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell [J].

Ridge, JP ;

Di Rosa, F ;

Matzinger, P .

NATURE, 1998, 393 (6684) :474-478

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