Preventive effects of protopanaxadiol and protopanaxatriol ginsenosides on liver inflammation and apoptosis in hyperlipidemic apoE KO mice

被引：9

作者：

Jang, Soojeong ^{[1
,2
]}

Lim, Yunsook ^{[3
]}

Valacchi, Giuseppe ^{[3
,4
]}

Sorn, Sungbin ^{[5
]}

Park, Hyon ^{[6
]}

Park, Na-Young ^{[3
]}

Lee, Myoungsook ^{[1
,7
]}

机构：

[1] Sungshin Womens Univ, Dept Food & Nutr, Nutr Biochem Lab, Seoul 136742, South Korea

[2] Korean Food Res Inst, Songnam, Gyeonggi Do, South Korea

[3] Kyung Hee Univ, Dept Food & Nutr, Seoul 130701, South Korea

[4] Univ Siena, Dept Biomed Sci, I-53100 Siena, Italy

[5] Korea Adv Inst Sci & Technol, Dept Biol Sci, Coll Life Sci & Bioengn, Taejon 305701, South Korea

[6] Kyung Hee Univ, Dept Sport Med, Coll Phys Educ, Yongin, South Korea

[7] Sungshin Womens Univ, Res Inst Obes Sci, Seoul 136742, South Korea

来源：

GENES AND NUTRITION | 2012年 / 7卷 / 02期

关键词：

Ginsenosides; Apoptosis; Apo E KO mice; LPO; NF kappa B; MAPK; Caspase; Cleaved PARP; Bcl-2; Hyperlipidemia; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; FACTOR-KAPPA-B; KINASE PATHWAYS; DEFICIENT MICE; HEPG2; CELLS; INSULIN; CHOLESTEROL; EXPRESSION; DISEASE;

D O I：

10.1007/s12263-011-0245-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Ginsenosides, bioactive compounds of Panax Ginseng C.A. Meyer, are divided into protopanaxadiol (PD) and protopanaxtriol (PT). The aim of this study was to evaluate the protective effects of different PD and PT combination ratios on liver inflammation and apoptosis in hyperlipidemic apo E KO mice. R1 (PD/PT = 1, high Rg(1) and Rb-1) and R2 (PD/PT = 2, high Re and Rd) extracts were intraperitoneally injected by 100 mg/kg/day at the 8th week. R1 and R2 improved atherogenic indices by increasing HDL and lowering total cholesterol (TC) and triacylglyceride (TG) selectively. R1 decreased lipid peroxides (LPO) level in plasma and liver tissue of hyperlipidemic mice, and R2 lowered plasma malondialdehyde(MDA) level. R1 and R2 not only regulated the expression of cyclooxygenase (COX)-2, I kappa B-alpha, phopho-ERK 1/2, and phopho-SAPK/JNK levels but also were significantly effective in blocking apoptotic signals, such as caspase-8, -9, as well as the cleavage of PARP in liver. Different combinational treatment of PD and PT extracts might ameliorate the liver inflammation and apoptosis in hyperlipidemic apo E KO mice, which is atherosclerotic animal model.

引用

页码：319 / 329

页数：11

共 48 条

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