Activation of BK channels may not be required for bitter tastant-induced bronchodilation

被引：46

作者：

Zhang, Cheng-Hai ^{[1
]}

Chen, Chen ^{[1
,2
]}

Lifshitz, Lawrence M. ^{[3
,4
]}

Fogarty, Kevin E. ^{[3
,4
]}

Zhu, Min-Sheng ^{[1
,2
]}

ZhuGe, Ronghua ^{[3
,5
]}

机构：

[1] Nanjing Univ, Model Anim Res Ctr, Nanjing, Jiangsu, Peoples R China

[2] Wenzhou Med Coll, Sch Life Sci, Wenzhou, Peoples R China

[3] Univ Massachusetts, Sch Med, Biomed Imaging Grp, Worcester, MA USA

[4] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA USA

[5] Univ Massachusetts, Sch Med, Dept Microbiol & Physiol Syst, Worcester, MA USA

来源：

NATURE MEDICINE | 2012年 / 18卷 / 05期

关键词：

AIRWAY SMOOTH-MUSCLE; CONTRACTION; SPARKS; CELLS;

D O I：

10.1038/nm.2733

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

引用

页码：648 / 650

页数：3

共 9 条

[1]

Acetylcholine-induced calcium signaling and contraction of airway smooth muscle cells in lung slices [J].

Bergner, A ;

Sanderson, MJ .

JOURNAL OF GENERAL PHYSIOLOGY, 2002, 119 (02) :187-198

[2]

Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction [J].

Deshpande, Deepak A. ;

Wang, Wayne C. H. ;

McIlmoyle, Elizabeth L. ;

Robinett, Kathryn S. ;

Schillinger, Rachel M. ;

An, Steven S. ;

Sham, James S. K. ;

Liggett, Stephen B. .

NATURE MEDICINE, 2010, 16 (11) :1299-U8

[3]

Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice [J].

He, Wei-Qi ;

Peng, Ya-Jing ;

Zhang, Wen-Cheng ;

Lv, Ning ;

Tang, Jing ;

Chen, Chen ;

Zhang, Cheng-Hai ;

Gao, Song ;

Chen, Hua-Qun ;

Zhi, Gang ;

Feil, Robert ;

Kamm, Kristine E. ;

Stull, James T. ;

Gao, Xiang ;

Zhu, Min-Sheng .

GASTROENTEROLOGY, 2008, 135 (02) :610-620

[4]

ACETYLCHOLINE ACTIVATES NONSELECTIVE CATION AND CHLORIDE CONDUCTANCES IN CANINE AND GUINEA-PIG TRACHEAL MYOCYTES [J].

JANSSEN, LJ ;

SIMS, SM .

JOURNAL OF PHYSIOLOGY-LONDON, 1992, 453 :197-218

[5]

RELAXATION OF ARTERIAL SMOOTH-MUSCLE BY CALCIUM SPARKS [J].

NELSON, MT ;

CHENG, H ;

RUBART, M ;

SANTANA, LF ;

BONEV, AD ;

KNOT, HJ ;

LEDERER, WJ .

SCIENCE, 1995, 270 (5236) :633-637

[6]

Spatial and temporal aspects of ACh-induced [Ca2+]i oscillations in porcine tracheal smooth muscle [J].

Prakash, YS ;

Pabelick, CM ;

Kannan, MS ;

Sieck, GC .

CELL CALCIUM, 2000, 27 (03) :153-162

[7]

Ion currents in smooth muscle cells from human small bronchioles:: Presence of an inward rectifier K+ current and three types of large conductance K+ channel [J].

Snetkov, VA ;

Ward, JPT .

EXPERIMENTAL PHYSIOLOGY, 1999, 84 (05) :835-846

[8]

SIGNAL-TRANSDUCTION AND REGULATION IN SMOOTH-MUSCLE [J].

SOMLYO, AP ;

SOMLYO, AV .

NATURE, 1994, 372 (6503) :231-236

[9]

Ca2+ Sparks Act as Potent Regulators of Excitation-Contraction Coupling in Airway Smooth Muscle [J].

ZhuGe, Ronghua ;

Bao, Rongfeng ;

Fogarty, Kevin E. ;

Lifshitz, Lawrence M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (03) :2203-2210

← 1 →