Increased excretion of urinary transforming growth factor beta 1 in patients with diabetic nephropathy

被引：49

作者：

Sato, H ^{[1
]}

Iwano, M ^{[1
]}

Akai, Y ^{[1
]}

Kurioka, H ^{[1
]}

Kubo, A ^{[1
]}

Yamaguchi, T ^{[1
]}

Hirata, E ^{[1
]}

Kanauchi, M ^{[1
]}

Dohi, K ^{[1
]}

机构：

[1] Nara Med Univ, Dept Internal Med 1, Kashihara, Nara 634, Japan

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 1998年 / 18卷 / 06期

关键词：

diabetic nephropathy; extracellular matrix; transforming growth factor beta 1;

D O I：

10.1159/000013415

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The accumulation of extracellular matrix in the glomeruli of human and experimental models of diabetic nephropathy is associated with disease progression. Transforming growth factor beta I (TGF-beta 1), which is a multifunctional peptide growth factor, plays a key role in the synthesis of extracellular matrix protein in vitro, and the expression of TGF-beta 1 is elevated in human and rat diabetic nephropathy. In this study, we measured the urinary TGF-beta 1 excretion in 57 patients with non-insulin-dependent diabetes mellitus and in 20 healthy volunteers to examine whether the determination of urinary TGF-beta 1 excretion would facilitate the evaluation of the degree of mesangial expansion in patients with diabetic nephropathy. Both active and total TGF-beta 1 levels in 24-hour urine samples collected from patients with diabetes mellitus and normal controls were measured using an enzyme-linked immunosorbent assay. We observed a higher excretion of urinary TGF-beta 1 in patients with diabetes mellitus than in normal controls. In addition, the urinary TGF-beta 1 excretion was elevated in patients with severe mesangial expansion. These results suggest that urinary TGF-beta 1 may represent one parameter that can be used to evaluate the progression of diabetic nephropathy.

引用

页码：490 / 494

页数：5

共 28 条

[1] TRANSFORMING GROWTH FACTOR-BETA(1) ENHANCES GLOMERULAR COLLAGEN-SYNTHESIS IN DIABETIC RATS [J].

BOLLINENI, JS ;

REDDI, AS .

DIABETES, 1993, 42 (11) :1673-1677

[2] TRANSFORMING GROWTH-FACTOR-BETA IN DISEASE - THE DARK SIDE OF TISSUE-REPAIR [J].

BORDER, WA ;

RUOSLAHTI, E .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (01) :1-7

[3] TRANSFORMING GROWTH FACTOR-B REGULATES PRODUCTION OF PROTEOGLYCANS BY MESANGIAL CELLS [J].

BORDER, WA ;

OKUDA, S ;

LANGUINO, LR ;

RUOSLAHTI, E .

KIDNEY INTERNATIONAL, 1990, 37 (02) :689-695

[4] SUPPRESSION OF EXPERIMENTAL GLOMERULONEPHRITIS BY ANTISERUM AGAINST TRANSFORMING GROWTH FACTOR-BETA-1 [J].

BORDER, WA ;

OKUDA, S ;

LANGUINO, LR ;

SPORN, MB ;

RUOSLAHTI, E .

NATURE, 1990, 346 (6282) :371-374

[5] TRANSFORMING GROWTH-FACTOR BETA-MODULATES THE EXPRESSION OF COLLAGENASE AND METALLOPROTEINASE INHIBITOR [J].

EDWARDS, DR ;

MURPHY, G ;

REYNOLDS, JJ ;

WHITHAM, SE ;

DOCHERTY, AJP ;

ANGEL, P ;

HEATH, JK .

EMBO JOURNAL, 1987, 6 (07) :1899-1904

[6] DIABETIC NEPHROPATHY - A CLINICAL AND PATHOLOGIC STUDY BASED ON RENAL BIOPSIES [J].

GELLMAN, DD ;

PIRANI, CL ;

SOOTHILL, JF ;

MUEHRCKE, RC ;

KARK, RM .

MEDICINE, 1959, 38 (04) :321-&

[7]

IGNOTZ RA, 1986, J BIOL CHEM, V261, P4337

[8] GLOMERULOSCLEROSIS INDUCED BY IN-VIVO TRANSFECTION OF TRANSFORMING GROWTH-FACTOR-BETA OR PLATELET-DERIVED GROWTH-FACTOR GENE INTO THE RAT-KIDNEY [J].

ISAKA, Y ;

FUJIWARA, Y ;

UEDA, N ;

KANEDA, Y ;

KAMADA, T ;

IMAI, E .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (06) :2597-2601

[9] Quantification of glomerular TGF-beta 1 mRNA in patients with diabetes mellitus [J].

Iwano, M ;

Kubo, A ;

Nishino, T ;

Sato, H ;

Nishioka, H ;

Akai, Y ;

Kurioka, H ;

Fujii, Y ;

Kanauchi, M ;

Shiiki, H ;

Dohi, K .

KIDNEY INTERNATIONAL, 1996, 49 (04) :1120-1126

[10]

LAIHO M, 1987, J BIOL CHEM, V262, P17467

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