Depressed natural killer cell cytotoxicity against Plasmodium falciparum-infected erythrocytes during first pregnancies

被引:47
作者
Bouyou-Akotet, MK
Issifou, S
Meye, JF
Kombila, M
Ngou-Milama, E
Luty, AJF
Kremsner, PG
Mavoungou, E
机构
[1] Univ Tubingen, Inst Trop Med, Dept Parasitol, D-72074 Tubingen, Germany
[2] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon
[3] Univ Sci Sante, Dept Parasitol Mycol Med Trop, Libreville, Gabon
[4] Univ Sci Sante, Dept Biochim, Libreville, Gabon
[5] Ctr Hosp Libreville, Serv Matern, Libreville, Gabon
关键词
D O I
10.1086/380646
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We measured natural killer (NK) cell cytotoxicity and cortisol and prolactin concentrations in peripheral venous blood samples obtained from pregnant Gabonese women at the time of delivery. The NK cell - mediated cytotoxicity against Plasmodium falciparum - infected erythrocytes in vitro was lower in samples obtained from primiparous women than in samples obtained from multiparous women; cortisol concentrations were significantly higher in primiparous women than in multiparous women, and prolactin concentrations were significantly lower. The highest cortisol concentrations were found in the plasma of P. falciparum - infected primiparous women. A positive correlation was found between cortisol concentration and parasite load; an inverse correlation was found between the magnitude of the NK cell cytolytic effect and cortisol production. A positive correlation was found between this effect and prolactin production. Thus, depressed NK cell cytotoxicity against P. falciparum - infected erythrocytes is correlated with high cortisol concentrations and may contribute to increased susceptibility to malaria during pregnancy.
引用
收藏
页码:342 / 347
页数:6
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