Rare and Common Genetic Events in Type 2 Diabetes: What Should Biologists Know?

被引：136

作者：

Bonnefond, Amelie ^{[1
,2
,3
]}

Froguel, Philippe ^{[1
,2
,3
,4
]}

机构：

[1] Lille Pasteur Inst, CNRS UMR8199, F-59000 Lille, France

[2] Univ Lille, F-59000 Lille, France

[3] EGID, F-59000 Lille, France

[4] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sch Publ Hlth, Dept Genom Common Dis, London W12 0NN, England

来源：

CELL METABOLISM | 2015年 / 21卷 / 03期

关键词：

GENOME-WIDE ASSOCIATION; FASTING PLASMA-GLUCOSE; OF-FUNCTION MUTATIONS; BODY-MASS INDEX; SUSCEPTIBILITY LOCUS; YOUNG MODY; INSULIN-RESISTANCE; LOW-FREQUENCY; RISK LOCI; FTO GENE;

D O I：

10.1016/j.cmet.2014.12.020

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Type 2 diabetes (T2D) had long been referred to as the "geneticist's nightmare.'' Genome-wide association studies have fully confirmed the polygenic nature of T2D, demonstrating the role of many genes in T2D risk. The increasingly busier picture of T2D genetics is quite difficult to understand for the diabetes research community, which can create misunderstandings with geneticists, and can eventually limit both basic research and translational outcomes of these genetic discoveries. The present review wishes to lift the fog around genetics of T2D with the hope that it will foster integrated diabetes modeling approaches from genetic defects to personalized medicine.

引用

页码：357 / 368

页数：12

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