Design and synthesis of aryl/hetarylmethyl phosphonate-UMP derivatives as potential glucosyltransferase inhibitors

被引：10

作者：

Bhattacharya, AK ^{[1
]}

Stolz, F ^{[1
]}

Schmidt, RR ^{[1
]}

机构：

[1] Univ Konstanz, Fachbereich Chem, D-78457 Constance, Germany

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 32期

关键词：

glycosyltransferases; transition-state; inhibitors; synthesis;

D O I：

10.1016/S0040-4039(01)00974-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel class of glucosyltransferase inhibitors has been designed and synthesised. The designed inhibitors 1-4 provide conformational mimicry of the transition-state in glucosyltransfer reactions. The key synthetic steps involve a Michaelis-Arbuzov reaction followed by coupling with uridine-5'-morpholidophosphate as activated UMP derivative. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：5393 / 5395

页数：3

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