Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21)

被引：5

作者：

Balbo, M ^{[1
]}

Barel, M ^{[1
]}

Lottin-Divoux, S ^{[1
]}

Jean, D ^{[1
]}

Frade, R ^{[1
]}

机构：

[1] INSERM, U 672, F-91030 Evry, France

来源：

FEMS MICROBIOLOGY LETTERS | 2005年 / 249卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

Mycoplasma infection; B lymphocyte proliferation; CD21;

D O I：

10.1016/j.femsle.2005.06.052

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human cell lines are often infected by mycoplama strains. We have demonstrated that when infected by Mycoplasma fermentans, human B lymphoma cell proliferation increased strongly. These infected B cells expressed a p45 kDa protein which interacted with the intracellular domain of CD21, the EBV/C3d receptor. p45 analysis demonstrated that this is a new gene which encodes an elongation factor originating from Mycoplasma fermentans. p45 interaction with CD21 was specific, there being no interaction with CD19. This is the first demonstration that Mycoplasma fermentans, in infecting human B cells, generates a p45 Mycoplasma component that interacts with CD21, which is involved in B cell proliferation. (c) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：359 / 366

页数：8

共 18 条

[1] Pep34, a synthetic peptide whose sequence corresponds to the intracytoplasmic domain of the epstein-barr virus receptor (CR2, CD21), regulates human B lymphocyte proliferation triggered through CR2. [J].