The inducible NO synthase is downregulated during apoptosis of malignant cells from B-cell chronic lymphocytic leukemia induced by flavopiridol and polyphenols

被引：6

作者：

Billard, C ^{[1
]}

Quiney, C

Tang, R

Kern, C

Ajchenbaum-Cymbalista, F

Dauzonne, D

Kolb, JP

机构：

[1] Ctr Biomed Cordeliers, INSERM, E355, Paris, France

[2] Hop Hotel Dieu, INSERM, EPI 9912, Paris, France

[3] Inst Curie, CNRS, UMR 176, F-75231 Paris, France

来源：

APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS | 2003年 / 1010卷

关键词：

B-cells; leukemia; apoptosis; NO; iNOS; flavopiridol; polyphenols;

D O I：

10.1196/annals.1299.069

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Downregulation of iNOS and NO is a pathway common for flavones and polyphenols, two distinct families of phytoalexins. Our data suggest that inhibition of the NO pathway could be one of the mechanisms involved in the proapoptotic properties of these phytoalexins in leukemia B-cells.

引用

页码：381 / 383

页数：3

共 5 条

[1]

Byrd JC, 1998, SEMIN ONCOL, V25, P65

[2] Synthesis and in vitro cytotoxicity of a series of 3-aminoflavones [J].