Surgical site infections following colorectal cancer surgery: a randomized prospective trial comparing common and advanced antimicrobial dressing containing ionic silver

被引：38

作者：

Biffi, Roberto ^{[1
,7
]}

Fattori, Luca ^{[2
]}

Bertani, Emilio ^{[3
,4
]}

Radice, Davide ^{[5
]}

Rotmensz, Nicole ^{[5
]}

Misitano, Pasquale ^{[1
,7
]}

Cenciarelli, Sabine ^{[1
,7
]}

Chiappa, Antonio ^{[3
,4
]}

Tadini, Liliana ^{[6
]}

Mancini, Marina ^{[6
]}

Pesenti, Giovanni ^{[2
]}

Andreoni, Bruno ^{[3
,4
]}

Nespoli, Angelo ^{[2
]}

机构：

[1] Univ Rostock, Dept Gen Thorac Vasc & Transplantat Surg, D-18057 Rostock, Germany

[2] Univ Rostock, Inst Pathol, D-18055 Rostock, Germany

[3] Univ Rostock, Dept Neurol, Neurodegenerat Res Lab NRL, D-18147 Rostock, Germany

[4] Univ Rostock, German Natl Dementia Ctr DZNE, D-18147 Rostock, Germany

[5] Univ Rostock, Inst Biostat & Informat Med & Ageing Res, D-18057 Rostock, Germany

[6] Univ Rostock, Inst Expt Surg, D-18057 Rostock, Germany

[7] European Inst Oncol, Div Abdominopelv & Minimally Invas Surg, I-43520141 Milan, Italy

来源：

WORLD JOURNAL OF SURGICAL ONCOLOGY | 2012年 / 10卷

关键词：

Colorectal cancer; Elective surgery; Hydrofiber dressing; Ionic silver; Surgical site infection; EXPRESSION; SURVIVAL; ANTIGEN; CARCINOMA; RESECTION;

D O I：

10.1186/1477-7819-10-94

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Background: An antimicrobial dressing containing ionic silver was found effective in reducing surgical-site infection in a preliminary study of colorectal cancer elective surgery. We decided to test this finding in a randomized, double-blind trial. Methods: Adults undergoing elective colorectal cancer surgery at two university-affiliated hospitals were randomly assigned to have the surgical incision dressed with Aquacel (R) Ag Hydrofiber dressing or a common dressing. To blind the patient and the nursing and medical staff to the nature of the dressing used, scrub nurses covered Aquacel (R) Ag Hydrofiber with a common wound dressing in the experimental arm, whereas a double common dressing was applied to patients of control group. The primary end-point of the study was the occurrence of any surgical-site infection within 30 days of surgery. Results: A total of 112 patients (58 in the experimental arm and 54 in the control group) qualified for primary end-point analysis. The characteristics of the patient population and their surgical procedures were similar. The overall rate of surgical-site infection was lower in the experimental group (11.1% center 1, 17.5% center 2; overall 15.5%) than in controls (14.3% center 1, 24.2% center 2, overall 20.4%), but the observed difference was not statistically significant (P = 0.451), even with respect to surgical-site infection grade 1 (superficial) versus grades 2 and 3, or grade 1 and 2 versus grade 3. Conclusions: This randomized trial did not confirm a statistically significant superiority of Aquacel (R) Ag Hydrofiber dressing in reducing surgical-site infection after elective colorectal cancer surgery.

引用

页数：15

共 23 条

[1]

[Anonymous], 1997, TNM CLASSIFICATION M, VFifth

[2]

Mucins and mucin binding proteins in colorectal cancer [J].