Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease

被引:362
作者
O'Donnell, DE
Lam, M
Webb, KA
机构
[1] Queens Univ, Dept Med, Resp Invest Unit, Kingston, ON K7L 3N6, Canada
[2] Queens Univ, Dept Epidemiol & Community Hlth, Kingston, ON K7L 3N6, Canada
关键词
D O I
10.1164/ajrccm.158.5.9804004
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Changes in lung hyperinflation, dyspnea, and exercise endurance are important outcomes in assessing therapeutic responses in chronic obstructive pulmonary disease (COPD). Therefore, we studied the reproducibility of Borg dyspnea ratings, inspiratory capacity (IC; to monitor lung hyperinflation), and endurance time during constant-load symptom-limited cycle exercise in 29 patients with CORD (FEV1 = 40 +/- 2% predicted; mean +/- SEM). Responsiveness was also studied by determining the acute effects of nebulized 500 mu g ipratropium bromide (IB) or saline placebo (P) on these measurements. During each of four visits conducted over an 8-wk period, spirometry and exercise testing were performed before and 1 h after receiving IB or P (randomized, double-blinded). Highly reproducible measurements included: endurance time (intraclass correlation R = 0.77, p < 0.0001); Borg ratings and IC at rest, at a standardized exercise time (STD), and at peak exercise (R > 0.6, p < 0.0001); and slopes of Borg ratings over time, oxygen consumption ((V) over dot O-2), and ventilation (R > 0.6, p < 0.0001). Responsiveness was confirmed by finding a significant drug effect for: change (Delta) in endurance time (p = 0.0001); Delta Borg(STD) and Delta Borg-time slopes (p < 0.05); and Delta IC at rest, at STD, and at peak exercise (p = 0.0001). With all completed visits, Delta Borg(STD) correlated better with Delta ICSTD than any other resting or exercise parameter (n = 115, r = -0.35, p < 0.001). We concluded that Borg dyspnea ratings, and measurements of IC and endurance time during submaximal cycle exercise testing are highly reproducible and responsive to change in severe COPD.
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页码:1557 / 1565
页数:9
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