Olanzapine plus fluoxetine treatment increases Nt-3 protein levels in the rat prefrontal cortex

被引：12

作者：

Agostinho, Fabiano R. ^{[1
,2
]}

Reus, Gislaine Z. ^{[1
,2
]}

Stringari, Roberto B. ^{[1
,2
]}

Ribeiro, Karine F. ^{[1
,2
]}

Pfaffenseller, Bianca ^{[3
,4
]}

Stertz, Laura ^{[3
,4
]}

Panizzutti, Bruna S. ^{[3
,4
]}

Kapczinski, Flavio ^{[3
,4
]}

Quevedo, Joao ^{[1
,2
]}

机构：

[1] Univ Extremo Catarinense, Lab Neurociencias, BR-88806000 Criciuma, SC, Brazil

[2] Univ Extremo Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, INCT TM, BR-88806000 Criciuma, SC, Brazil

[3] Hosp Clin Porto Alegre, Lab Psiquiatria Mol, BR-90035003 Porto Alegre, RS, Brazil

[4] Hosp Clin Porto Alegre, Ctr Pesquisas, INCT TM, BR-90035003 Porto Alegre, RS, Brazil

来源：

NEUROSCIENCE LETTERS | 2011年 / 497卷 / 02期

关键词：

Brain-derived-neurotrophic factor; Nerve growth factor; Neurotrophin-3; Fluoxetine; Olanzapine; Mood disorder; NERVE GROWTH-FACTOR; NEUROTROPHIC FACTOR; BIPOLAR DISORDER; MESSENGER-RNA; PLASMA-LEVELS; CATECHOLAMINE METABOLITES; ATYPICAL ANTIPSYCHOTICS; DIFFERENTIAL REGULATION; DOUBLE-BLIND; BDNF LEVELS;

D O I：

10.1016/j.neulet.2011.04.039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Evidence is emerging for a role for neurotrophins in the treatment of mood disorders. In this study, we evaluated the effects of chronic administration of fluoxetine, olanzapine and the combination of fluoxetine/olanzapine on the brain-derived-neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin-3 (NT-3) in the rat brain. Wistar rats received daily injections of olanzapine (3 or 6 mg/kg) and/or fluoxetine (12.5 or 25 mg/kg) for 28 days, and we evaluated for BDNF, NGF and NT-3 protein levels in the prefrontal cortex, hippocampus and amygdala. Our results showed that treatment with fluoxetine and olanzapine alone or in combination did not alter BDNF in the prefrontal cortex (p = 0.37), hippocampus (p = 0.98) and amygdala (p = 0.57) or NGF protein levels in the prefrontal cortex (p = 0.72), hippocampus (p = 0.23) and amygdala (p = 0.64), but NT-3 protein levels were increased by olanzapine 6 mg/kg/fluoxetine 25 mg/kg combination in the prefrontal cortex (p = 0.03). in the hippocampus (p = 0.83) and amygdala (p = 0.88) NT-3 protein levels did not alter. Finally, these findings further support the hypothesis that NT-3 could be involved in the effect of treatment with antipsychotic and antidepressant combination in mood disorders. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：99 / 103

页数：5

共 67 条

[1]

Treatment with olanzapine, fluoxetine and olanzapine/fluoxetine alters citrate synthase activity in rat brain [J].