Proteolysis: anytime, any place, anywhere?

被引：65

作者：

Pines, J

Lindon, C

机构：

[1] Wellcome Trust Canc Res UK, Gurdon Inst, Cambridge CB2 1QN, England

[2] Dept Zool, Cambridge CB2 1QN, England

来源：

NATURE CELL BIOLOGY | 2005年 / 7卷 / 08期

关键词：

D O I：

10.1038/ncb0805-731

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteolysis via the ubiquitin-proteasome system (UPS) is a rapid and effective method of degrading a specific protein at a specific time, and in many cases a protein is degraded only in response to a particular cellular signal or event. However, an added dimension to the control of protein degradation is possible because the ubiquitin system can be spatially regulated. Controlling where a protein is degraded can enhance the specificity and timing of proteolysis, generate asymmetry and maintain sub-compartments even in the mitotic cell. Here, we discuss this aspect of the UPS.

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页码：731 / 735

页数：5

相关论文

共 61 条

[1] The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint [J].

Acquaviva, C ;

Herzog, F ;

Kraft, C ;

Pines, J .

NATURE CELL BIOLOGY, 2004, 6 (09) :892-U82

[2] CHANGES IN INTRACELLULAR-LOCALIZATION OF PROTEASOMES IN IMMORTALIZED OVARIAN GRANULOSA-CELLS DURING MITOSIS ASSOCIATED WITH A ROLE IN CELL-CYCLE CONTROL [J].

AMSTERDAM, A ;

PITZER, F ;

BAUMEISTER, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :99-103

[3] Cdc5 interacts with the Wee1 kinase in budding yeast [J].

Bartholomew, CR ;

Woo, SH ;

Chung, YS ;

Jones, C ;

Hardy, CFJ .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (15) :4949-4959

[4] The proteasome:: Paradigm of a self-compartmentalizing protease [J].

Baumeister, W ;

Walz, J ;

Zühl, F ;

Seemuller, E .

CELL, 1998, 92 (03) :367-380

[5] Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4 [J].

Blondel, M ;

Galan, JM ;

Chi, Y ;

Lafourcade, C ;

Longaretti, C ;

Deshaies, RJ ;

Peter, M .

EMBO JOURNAL, 2000, 19 (22) :6085-6097

[6] Degradation of Hof1 by SCFGrr1 is important for actomyosin contraction during cytokinesis in yeast [J].

Blondel, M ;

Bach, S ;

Bamps, S ;

Dobbelaere, J ;

Wiget, P ;

Longaretti, C ;

Barral, Y ;

Meijer, L ;

Peter, M .

EMBO JOURNAL, 2005, 24 (07) :1440-1452

[7] Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation [J].

Campbell, DS ;

Holt, CE .

NEURON, 2001, 32 (06) :1013-1026

[8] SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 [J].

Carrano, AC ;

Eytan, E ;

Hershko, A ;

Pagano, M .

NATURE CELL BIOLOGY, 1999, 1 (04) :193-199

[9] Temporal and spatial control of cyclin B1 destruction in metaphase [J].

Clute, P ;

Pines, J .

NATURE CELL BIOLOGY, 1999, 1 (02) :82-87

[10] CRM1/Ran-mediated nuclear export of p27Kip1 involves a nuclear export signal and links p27 export and proteolysis [J].

Connor, MK ;

Kotchetkov, R ;

Cariou, S ;

Resch, A ;

Lupetti, R ;

Beniston, RG ;

Melchior, F ;

Hengst, L ;

Slingerland, JM .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (01) :201-213

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